Definitions and classification of DI Diabetes InsipidusType Clinical features Polyuria Increased urine output > 3L/day in adults Etiologies Diabetes insipidus High protein diet with urea elimination Hyperglycemia Medications (eg, SGLT2 inhibitors, diuretics) Post-obstructive diuresis Primary polydipsia Central diabetes insipidus (CDI) MechanismADH also known as vasopressin Decreased release of antidiuretic hormone (ADH) from pituitary Affected sites Hypothalamic osmoreceptors Superior portion of the supra-optico-hypophyseal tract Supraoptic or paraventricular nuclei Nephrogenic diabetes insipidus (NDI) Mechanism Resistance to ADH in collecting tubules of kidney Affected sites Collecting tubules Renal medulla with disrupted countercurrent mechanism Thick ascending loop of Henle with decreased sodium chloride reabsorption (Next Lesson) Central diabetes insipidus (CDI) Back to Diabetes Insipidus No Comments Comments are closed.
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