["Abnormal Liver Function Tests","Acne vulgaris","Acute Bronchitis","Acute Kidney Injury","Adrenal Insufficiency","Allergic Rhinitis","Anemia","Approach to Abdominal Pain","Approach to Acid Base Disorders","Approach to Bone Loss","Approach to Bright Red Blood Per Rectum (BRBPR)","Approach to Cervical cancer screening","Approach to Chest Pain","Approach to Constipation","Approach to Cough","Approach to Dementia","Approach to Diarrhea","Approach to Dizziness","Approach to Dysphagia and Odynophagia","Approach to EKG","Approach to Falls","Approach to Fatigue","Approach to Fever","Approach to Hematuria","Approach to Hemoptysis","Approach to Hypercoagulable Disorders","Approach to Hyperkalemia","Approach to Hypernatremia","Approach to Hyperprolactinemia","Approach to Hypocalcemia","Approach to Hypoglycemia","Approach to Hypokalemia","Approach to Hyponatremia","Approach to Hypothyroidism","Approach to Jaundice","Approach to Low Back Pain","Approach to Muscle weakness","Approach to Nausea and Vomiting","Approach to Neck Pain","Approach to Palpitations","Approach to Peripheral Edema","Approach to Proteinuria","Approach to Seizure","Approach to Shortness of Breath (Dyspnea)","Approach to Splenomegaly","Approach to Syncope","Approach to Thyroid Nodule","Approach to Unintentional Weight Loss","Asthma","Bell\u2019s Palsy","Benign Prostatic Hyperplasia (BPH)","Bleeding Disorders","Breast cancer screening","Bronchiectasis","Celiac disease","Chronic Kidney Disease","Chronic Obstructive Pulmonary Disease (COPD)","Cirrhosis","Colon cancer screening","Congestive Heart Failure (CHF)","Crohn\u2019s Disease","Cushing\u2019s Syndrome","Delirium","Depression","Diabetes Insipidus","Diverticulosis and Diverticulitis","Dyspepsia","Gastroesophageal Reflux Disease (GERD)","Generalized Anxiety Disorder (GAD)","Headache","Hearing loss","Helicobacter pylori (H. pylori)","Hemorrhoids","Hepatitis B","Hepatitis C","Hypercalcemia","Hypertension","Irritable Bowel Syndrome (IBS)","Kidney stones","Leukocytosis","Leukopenia","Lipid Disorders","Lymphadenopathy","Meningitis and Encephalitis","Microscopic Colitis","Obstructive Sleep Apnea","Pancreatitis","Peptic Ulcer Disease (PUD)","Pericardial Disease","Pneumonia","Stroke and TIA","Ulcerative Colitis","Upper Gastrointestinal Bleeding","Urinary Dysfunction","Urinary Tract Infection (UTI)","Vitamin D deficiency"]

Hepatitis C

Background of hepatitis C virus (HCV)

Type	Clinical features
Prevalence	*High prevalence (> 2%)* China Eastern Mediterranean Egypt India Pakistan *Moderate prevalence (1-2%)* Africa Europe *Low prevalence ( < 1%)* North & South America Southeast Asia Western Pacific countries
Virology	Single stranded RNA virus from family Flaviviridae *Viral replication cycle* Viral RNA translated into polyprotein by host cells after viral entry Viral protease complex NS3 and NS4A proteins work together to cleave polyprotein into mature viral proteins NS5A and NS5B help modulate further viral replication and release viral particle from host cell *Genotypes* Genotype 1 60-75% of patients in US, Latin America, and Europe Subtypes include 1a and 1b Genotype 2 ~15% of patients) in US, Latin America, and Europe Subtypes include 2a and 2b Genotype 3 More common in India, Far East, and Australia Genotype 4 Most common in Africa and Middle East Genotype 5 Most common in South Africa Genotype 6 Most common in Hong Kong and Vietnam
*Possible modes of viral transmission*	Blood transfusion Mother to child in utero, during chilbirth, or after childbirth Organ transplant from infected donors Sexual transmission *Percutaneous innoculation by contaminated equipment* Accidental needle stick Acupuncture Body piercing Syringes and needles by IV drug use Tattooing

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