Anatomy of adrenal gland Cushing’s SyndromeLocation Function Adrenal cortexZona glomerulosaOuter layer of adrenal gland Secretes mineralocorticoids (eg, aldosterone) to regulate sodium and potassium Zona fasciculataMiddle layer of cortex Secretes glucocorticoids (eg, cortisol) Stimulated by ACTH released by pituitary Zona reticularisSecretes sex steroids (eg, androgens, estrogen precursors, progesterone) Adrenal medullaInner region of the adrenal gland Secretes catecholamines (eg, epinephrine, norepinephrine) Hypothalamic pituitary axis Hypothalamus secretes corticotropin releasing hormone (CRH), which stimulates pituitary to secrete ACTH ACTH stimulates adrenal gland to secrete cortisol Cortisol provides feedback inhibition loop for both ACTH and CRH (Next Lesson) Classification of adrenal disorders Back to Cushing’s Syndrome No Comments Comments are closed.
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