| Type |
Clinical features |
| Prevalence |
- Moderate prevalence (1-2%)
-
- Western Pacific countries
|
| Virology |
- Single stranded RNA virus from family Flaviviridae
-
- Viral RNA translated into polyprotein by host cells after viral entry
-
- Viral protease complex NS3 and NS4A proteins work together to cleave polyprotein into mature viral proteins
-
- NS5A and NS5B help modulate further viral replication and release viral particle from host cell
-
-
- 60-75% of patients in US, Latin America, and Europe
-
-
- Subtypes include 1a and 1b
-
-
- ~15% of patients) in US, Latin America, and Europe
-
-
- Subtypes include 2a and 2b
-
-
- More common in India, Far East, and Australia
-
-
- Most common in Africa and Middle East
-
-
- Most common in South Africa
-
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- Most common in Hong Kong and Vietnam
|
| Possible modes of viral transmission |
- Mother to child in utero, during chilbirth, or after childbirth
- Organ transplant from infected donors
- Percutaneous innoculation by contaminated equipment
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- Syringes and needles by IV drug use
|
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