Clinical presentation of hyperprolactinemia Approach to HyperprolactinemiaType Clinical features Normal Physiology Prolactin secreted by lactotroph cells in pituitary gland Levels increase significantly during pregnancy Prolactin can also increase with physical exertion, stress, and nipple stimulation during breastfeeding Normal level ~ 20 ng/mL Hyperprolactinemia suppresses pulsatile GnRH release to cause hypogonadotropic hypogonadism Premenopausal women Hypogonadism due to inhibition of GnRH release Prolactin 20-50 ng/mL Infertility Prolactin 50-100 ng/mL Oligomenorrhea or amenorrhea Infertility Prolactin > 100 ng/mL Hot flashes Vaginal dryness Plus above findings Possible decrease in bone density Possible galactorrhea Postmenopausal women Already have underlying hypogonadal symptoms due to menopause Can have headaches or impaired vision Men Hypogonadism due to decreased testosterone secretion Decreased energy and libido Decreased muscle mass Hair loss Osteoporosis Erectile dysfunction Possible infertility Possible galactorrhea (Next Lesson) Causes of hyperprolactinemia Back to Approach to Hyperprolactinemia No Comments Comments are closed.
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