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Common liver function tests (LFTs) | The Art of Clinical Medicine
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Abnormal Liver Function Tests

Common liver function tests (LFTs)

Abnormal Liver Function Tests

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Type	Clinical Features
Aspartate aminotransferase (AST, previously called SGOT)	Main locations Liver Cardiac muscle Skeletal muscle Kidney Brain
Alanine aminotransferase (ALT, previously called SGPT)	Predominantly in liver
Alkaline phosphate	Mainly in liver, bone, placenta
Gamma-glutamyl transpeptidase (GGT)	Main locations Liver and biliary epithelial cells Kidney Seminal vesicles Pancreas Spleen Heart Brain Conditions with isolated GGT elevation Alcoholism Pancreatic disease Renal failure Medications COPD
Hepatic function studies	Albumin Prothrombin time/international normalized ratio (PT/INR)

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